Enzymic synthesis and metabolism of malonyl coenzyme A and glutaryl coenzyme A.

Enzymic synthesis and reduction of malonyl semialdehyde-coenzyme A.

The participation of malonyl coenzyme A in the biosynthesis of mevalonic acid.

A number of laboratories (l-4) have investigated the biosynthesis of mevalonic acid from acetate or acetyl coenzyme ,4 by yeast and animal enzyme systems. These investigations have indicated that acetoacetyl coenzyme A and P-hydroxy-P-methylglutaryl coenzyme A glutaryl are intermediates in the formation of mevalonic acid. However, the synthesis in vitro of sterols from acetate by subcellular, r...

Fat Metabolism in Higher Plants: LVII. A Comparison of Fatty Acid-Synthesizing Enzymes in Chloroplasts Isolated from Mature and Immature Leaves of Spinach.

Chloroplasts isolated from immature leaves of spinach (Spinacia oleracea) differ in enzyme levels from those isolated from mature leaves. On a chlorophyll basis, immature chloroplast preparations had 5- to 6-fold higher capacity to synthesize fatty acids from 2-(14)C-acetate compared to plastids isolated from mature leaves. This difference was correlated with higher activities for the enzymes, ...

Regulator of fatty acid metabolism, acetyl coenzyme a carboxylase 1, controls T cell immunity.

Fatty acids (FAs) are essential constituents of cell membranes, signaling molecules, and bioenergetic substrates. Because CD8(+) T cells undergo both functional and metabolic changes during activation and differentiation, dynamic changes in FA metabolism also occur. However, the contributions of de novo lipogenesis to acquisition and maintenance of CD8(+) T cell function are unclear. In this ar...

Activation of fatty acid synthesis in cell-free extracts of Saccharomyces cerevisiae.

Fatty acid synthesis from acetate in extracts of Saccharomyces cerevisiae strain LK2G12 was shown to be stimulated by alpha-glycerophosphate and citrate, and by a number of compounds related to them. Magnesium was shown to stimulate fatty acid synthesis from acetyl-coenzyme A but not from malonyl-coenzyme A, thus indicating the site of stimulation of fatty acid synthesis to be the acetyl-coenzy...